Clinical, histological, and endoscopic characteristics of Helicobacter pylori infection in patients attended at a public pediatric hospital in Peru

Authors

DOI:

https://doi.org/10.58597/rpe.v2i2.62

Keywords:

Helicobacter pylori, Diagnosis, Children, Endoscoy, Gastritis

Abstract

Objective: To determine the clinical, endoscopic, and histological characteristics of Helicobacter pylori infection in children at a public pediatric hospital in 2013.

Materials and Methods: It is an observational, descriptive, cross-sectional, and retrospective study. A census sampling was collected to gather information from medical records and from pathologic and endoscopic reports of patients under 18 years old treated at the Department of Pediatric Gastroenterology. The statistical software Stata v.14.0 was used for the analysis. The Institutional Research Ethics Committee of the Instituto Nacional de Salud del Niño approved the study (code PI-52-2020).

Results: Out of a total of 201 medical records of pediatric patients with Helicobacter pylori infection treated in 2013, 58.2% had abdominal pain as the main symptom. The most common location of gastric mucosal lesions was predominantly the antrum (62.2%), and the gastric body (25.9%). Regarding histopathological findings, most patients had mild (51.7%) or moderate (40.3%) chronic gastritis.

Conclusion: This study reveals that abdominal pain was the primary symptom in over half of pediatric patients with Helicobacter pylori infection. Gastric mucosal lesions were most frequently observed in the antrum, and gastric biopsies showed predominantly superficial chronic gastritis with mild to moderate inflammation.

Downloads

Download data is not yet available.

References

Yuan C, Adeloye D, Luk TT, Huang L, He Y, Xu Y; Global Health Epidemiology Research Group. The global prevalence of and factors associated with Helicobacter pylori infection in children: a systematic review and meta-analysis. Lancet Child Adolesc Health. 2022;6(3):185-194. doi: 10.1016/S2352-4642(21)00400-4.

Tirado-Hurtado I, Carlos C, Lancho L, Alfaro A, Ponce R, Schwarz LJ, et al. Helicobacter pylori: History and facts in Peru. Crit Rev Oncol Hematol. 2019;134:22-30. doi: 10.1016/j.critrevonc.2018.12.005.

Curado M, de Oliveira M, de Araújo Fagundes M. Prevalence of Helicobacter pylori infection in Latin America and the Caribbean populations: A systematic review and meta-analysis. Cancer Epidemiol. 2019;60:141-148. doi: 10.1016/j.canep.2019.04.003.

Mehrabani S. Helicobacter pylori Infection in Children: a Comprehensive Review. Maedica (Bucur). 2019;14(3):292-297. doi: 10.26574/maedica.2019.14.3.292.

Galicia G, Alarcón T, Alonso N, Borrell B, Botija G, Cilleruelo M, et al. Management of Helicobacter pylori infection in the pediatric age. An Pediatr. 2021;95(5):383.e1-383.e9. doi: 10.1016/j.anpede.2021.05.004.

Spee L, Madderom M, Pijpers M, van Leeuwen Y, Berger M. Association between helicobacter pylori and gastrointestinal symptoms in children. Pediatrics. 2010 Mar;125(3):e651-69. doi: 10.1542/peds.2010-0941.

Aguilera Matos I, Diaz Oliva S, Escobedo A, Villa Jiménez O, Velazco Villaurrutia Y. Helicobacter pylori infection in children. BMJ Paediatr Open. 2020;4(1):e000679. doi: 10.1136/bmjpo-2020-000679.

Hojati S, Kokabpeyk S, Yaghoubi S, Joukar F, Asgharnezhad M, Mansour-Ghanaei F. Helicobacter pylori infection in Iran: demographic, endoscopic and pathological factors. BMC Gastroenterol. 2021;21(1):355. doi: 10.1186/s12876-021-01931-1.

Kato S, Shimizu T, Toyoda S, Gold B, Ida S, Ishige T; Japanese Society for Pediatric Gastroenterology, Hepatology and Nutrition. The updated JSPGHAN guidelines for the management of Helicobacter pylori infection in childhood. Pediatr Int. 2020; 62(12):1315-1331. doi: 10.1111/ped.14388.

Instituto de Evaluación de Tecnologías en Salud e Investigación. Guía de Práctica Clínica para el Diagnóstico y Manejo de la Infección por Helicobacter pylori en Enfermedades Gastroduodenales: Guía en Versión Corta. Lima: EsSalud; 2020

Chatrangsun B, Vilaichone R. Endoscopic Diagnosis for H. pylori Infection: White Light Imaging (WLI) vs. Image-Enhanced Endoscopy (IEE). Asian Pac J Cancer Prev. 2021;22(9):3031-3038. doi: 10.31557/APJCP.2021.22.9.3031.

Hernández-Vásquez A, Bautista-Pariona A, Bendezu-Quispe G. Peruvian scientific production on Helicobacter pylori: a bibliometric analysis. Rev. gastroenterol. Perú [Internet]. 2020; 40(4): 329-335. Disponible en: http://dx.doi.org/10.47892/rgp.2020.404.1207.

Muñoz Urribarri A, Cok García J, Bussalleu Rivera A, Cetraro Cardó D, Maruy Saito A, Takami Angeles F. Helicobacter pylori en niños atendidos en el Hospital Nacional Cayetano Heredia durante los años 2003 al 2006. Rev. gastroenterol. Perú [Internet]. 2008; 28(2):109-118. Disponible en: http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S1022-51292008000200002&lng=es.

Jara-Romero L, Sánchez-Figueroa C, Santana-Bazalar D, León-Jiménez F, Cubas-Benavides F. Frecuencia de Helicobacter pylori y características clínicas en niños con endoscopía digestiva alta de un hospital de Lambayeque: 2007-2010. Revista del Cuerpo Médico del Hospital Nacional Almanzor Aguinaga Asenjo. 2013; 6(3):28-32. Disponible en: https://docs.bvsalud.org/biblioref/2020/03/1052520/rcm-v6-n3-2013_pag28-32.pdf

Castillo Contreras O, Maguiña Quispe J, Benites Goñi H, Chacaltana Mendoza A, Guzmán Calderón E, Dávalos Moscol Milagros, et al. Prevalencia de Helicobacter pylori en pacientes ambulatorios sintomáticos de la Red Rebagliati (EsSalud), Lima, Perú, en el período 2010 - 2013. Rev. gastroenterol. Perú. 2016; 36(1): 49-55. Disponible en: http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S1022-51292016000100007&lng=es.

Jafar S, Jalil A, Soheila N, Sirous S. Prevalence of helicobacter pylori infection in children, a population-based cross-sectional study in west iran. Iran J Pediatr. 2013;23(1):13-8. Available in: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574986/

Mejia C, Vera C, Huiza-Espinoza L. Association between follicular gastritis and Helicobacter pylori in children seen at a public hospital in Peru. Rev Gastroenterol Mex. 2016; 81(2):80-5. doi: 10.1016/j.rgmx.2016.01.003.

Hasosah M, Satti M, Shehzad A, Alsahafi A, Sukkar G, Alzaben A, Sunaid A, Ahmed A, AlThubiti S, Mufti A, Jacobson K. Prevalence and risk factors of Helicobacter pylori infection in Saudi children: a three-year prospective controlled study. Helicobacter. 2015;20(1):56-63. doi: 10.1111/hel.12172.

Galal YS, Ghobrial CM, Labib JR, Abou-Zekri M. Helicobacter pylori among symptomatic Egyptian children: prevalence, risk factors, and effect on growth. J Egypt Public Health Assoc. 2019;94(1):17. doi: 10.1186/s42506-019-0017-6.

Kayali S, Manfredi M, Gaiani F, Bianchi L, Bizzarri B, Leandro G, Di Mario F, De' Angelis GL. Helicobacter pylori, transmission routes and recurrence of infection: state of the art. Acta Biomed. 2018;89(8-S):72-76. doi: 10.23750/abm.v89i8-S.7947.

Instituto Nacional de Estadística e Informática. Perú: Compendio Estadístico Lima; Lima: INEI; 2020: 473pp. Disponible en: https://www.inei.gob.pe/media/MenuRecursivo/publicaciones_digitales/Est/Lib1847/libro.pdf

Aliaga Ramos J, Cedrón Cheng H, Pinto Valdivia J. Comparación de la prevalencia de infección por Helicobacter pylori en pacientes con dispepsia entre dos instituciones de diferente estrato socioeconómico en el período 2017-2018. Rev. Gastroenterol. Perú. 2019; 39(3): 211-214. Disponible en: http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S1022-51292019000300002&lng=es.

Rosu O, Gimiga N, Stefanescu G, Anton C, Paduraru G, Tataranu E, et al. Helicobacter pylori Infection in a Pediatric Population from Romania: Risk Factors, Clinical and Endoscopic Features and Treatment Compliance. J Clin Med. 2022;11(9):2432. doi: 10.3390/jcm11092432.

Toscano E, Madeira F, Dutra-Rulli M, Gonçalves L, Proença M, Borghi V, et al. Epidemiological and Clinical-Pathological Aspects of Helicobacter pylori Infection in Brazilian Children and Adults. Gastroenterol Res Pract. 2018 ;2018:8454125. doi: 10.1155/2018/8454125.

Al Kirdy F, Rajab M, El-Rifai N. Helicobacter pylori Infection: Clinical, Endoscopic, and Histological Findings in Lebanese Pediatric Patients. Int J Pediatr. 2020;2020:4648167. doi: 10.1155/2020/4648167.

Nguyen TC, Tang NLC, Le GKN, Nguyen VT, Nguyen KHG, Che TH, et al. Helicobacter pylori Infection and Peptic Ulcer Disease in Symptomatic Children in Southern Vietnam: A Prospective Multicenter Study. Healthcare (Basel). 2023;11(11):1658. doi: 10.3390/healthcare11111658.

Yang HR. Updates on the Diagnosis of Helicobacter pylori Infection in Children: What Are the Differences between Adults and Children? Pediatr Gastroenterol Hepatol Nutr. 2016;19(2):96-103. doi: 10.5223/pghn.2016.19.2.96.

Carabaño Aguado I, La Orden Izquierdo E, Santonja Garriga C, Pelayo García F, Llorente Otones L, Manzarbeitia Arambarri F. Patogenia y expresión endoscópica de la infección por H. pylori en niños. Rev Pediatr Aten Primaria. 2012; 14 (53): 69-74. doi. https://dx.doi.org/10.4321/S1139-76322012000100012.

Cárdenas-Mondragón MG, Carreón-Talavera R, Camorlinga-Ponce M, Gomez-Delgado A, Torres J, Fuentes-Pananá EM. Epstein Barr virus and Helicobacter pylori co-infection are positively associated with severe gastritis in pediatric patients. PLoS One. 2013;8(4):e62850. doi: 10.1371/journal.pone.0062850.

Andrade Ruiseco M, García Pérez W, Davas Andrade Y, Hernández Reyes L. Importancia de Helicobacter pylori en Pediatría, estudio diagnóstico en un grupo de niños. Rev Pediatría Cubana. 2017; 89(3). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75312017000300003&lng=es.

Downloads

Published

2023-12-07

Issue

Section

Artículos originales

How to Cite

1.
Celi-Pérez MD. Clinical, histological, and endoscopic characteristics of Helicobacter pylori infection in patients attended at a public pediatric hospital in Peru. Rev Pediatr Espec [Internet]. 2023 Dec. 7 [cited 2026 Jun. 5];2(2):62-7. Available from: https://revistapediatricae.insn.gob.pe/index.php/rpe/article/view/62